I recently discovered that After Effects (CS3) wasn’t deleting it’s Media Cache files when I quit the application. The folder had swelled to 6.19 GB.
I’m not sure if this is a bug in CS3, or if all versions of AE suffered from this problem. But, if you’re an After Effects user you may want to make sure you haven’t (unnecessarily) lost some drive space. On a Mac, the folder is located at ~/Library/Caches/Adobe/After Effects CS3/Media Cache Files. You can either manually toss the content of the folder, or you can open AE on go to the Memory & Cache preferences and click, Clean Database & Cache.